桃花汤治疗溃疡性结肠炎疗效的系统评价.docx

桃花汤治疗溃疡性结肠炎疗效的系统评价

陆艾阳子高卉沈浩然郭秋红

[摘要]?目的?評价桃花汤治疗溃疡性结肠炎的临床疗效。方法?检索中国知网、万方数据知识服务平台、维普网、中国生物医学数据库、PubMed、Web?of?science、Cochrane?library，筛选文献并采集文献相关信息，使用Review?Manager?5.3评价偏倚风险并对各疗效指标进行系统评价。结果?检索获得546篇文献，经过剔重和筛选最终纳入16篇文献。Meta分析显示临床总有效率：RR=1.19，95%CI：1.14～1.24，P0.001，结肠镜积分：MD=-0.61，95%CI：-1.11～-0.11，P=0.020，肿瘤坏死因子-α：MD=-22.18，95%CI：-36.70～-7.66，P=0.003，C反应蛋白：MD=-10.85，95%CI：-30.48～8.77，P=0.280，不良反应发生率：RR=0.40，95%CI：0.24～0.65，P0.001。结论?桃花汤治疗溃疡性结肠炎在临床总有效率、结肠镜积分、肿瘤坏死因子-α及不良反应发生率方面优于对照组。

[关键词]?桃花汤；溃疡性结肠炎；系统评价；Meta分析

[中图分类号]?R516??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.11.015

Systematic?review?of?therapeutic?effect?of?taohua?decoction?on?ulcerative?colitis

LU?Aiyangzi1，2，?GAO?Hui1，3，?SHENG?Haoran1，?GUO?Qiuhong1

1.Hebei?University?of?Chinese?Medicine，?College?of?Pharmacy，?Shijiazhuang?050000，?Hebei，?China;?2.Department?of?Chinese?Medicine，?Wuxi?Hospital?of?Traditional?Chinese?Medicine，?Wuxi?214100，?Jiangsu，?China;?3.2nd?Department?of?Nephrology，?Hebei?Provincial?Hospital?of?Traditional?Chinese?Medicine，?Shijiazhuang?050100，?Hebei，?China

[Abstract]?Objective?To?evaluate?the?clinical?efficacy?of?Taohua?Decoction?in?treating?ulcerative?colitis.?Methods?Searching?CNKI，?Wanfang，?Weipu，?China?Biomedical?Database，?PubMed，?Web?of?science，?and?Cochrane?library，?Screening?literature?and?collecting?literature?related?information.?Using?Review?Manager?5.3?to?evaluate?the?risk?of?bias?and?systematically?evaluate?efficacy?indicators.?Results?A?total?of?546?articles?were?retrieved，?and?16?were?eventually?included?after?censoring?and?screening.?Meta?analysis?showed?that?total?clinical?effective?rate：?RR=1.19，?95%CI：?1.14–1.24，?P0.001.?Colonoscopy?score：?MD=-0.61，?95%CI：?-1.11–-0.11，?P=0.02.?Tumor?necrosis?factor?（TNF）-α：?MD=-22.18，?95%CI：-36.70–-7.66，?P=0.003.?C-reactive?protein：?MD=?-10.85，?95%CI：?-30.48–8.77，?P=0.28.?Incidence?of?adverse?reactions：?RR=0.40，?95%CI：?0.24–0.65，?P0.001.?Conclusion?The?total?clinical?effective?rate，?colonoscopy?score，?TNF-α?and?incidence?o