沙库巴曲缬沙坦在慢性心力衰竭患者中的应用效果.docx

沙库巴曲缬沙坦在慢性心力衰竭患者中的应用效果

钟韶春廖永生张清录

[关键词]?慢性心力衰竭；沙库巴曲缬沙坦；N末端脑钠肽前体；心功能

[中图分类号]?R541??????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.04.019

The?application?effect?of?sacubitril?valsartan?in?patients?with?chronic?heart?failure

ZHONG?Shaochun，?LIAO?Yongsheng，?ZHANG?Qinglu

Department?of?Cardiovascular，?Xinyu?Yuanhe?Hospital，?Xinyu?338000，?Jiangxi，?China

[Abstract]?Objective?To?explore?the?application?effect?of?sacubitril?valsartan?in?patients?with?chronic?heart?failure?（CHF）.?Methods?A?total?of?66?CHF?patients?admitted?to?Xinyu?Yuanhe?Hospital?from?September?2021?to?September?2022?were?selected?and?divided?into?control?group?and?study?group?according?to?random?number?table?method，?with?33?cases?in?each?group.?The?control?group?was?treated?with?benazepril?+?spironolactone?+?metoprolol，?and?the?study?group?was?treated?with?sacubitril?valsartan?+?spironolactone?+?metoprolol.?The?clinical?efficacy，?ventricular?remodeling，?cardiac?function，?serum?factor?levels?and?adverse?reactions?were?compared?between?two?groups.?Results?The?total?effective?rate?in?study?group?was?significantly?higher?than?that?in?control?group?（χ2=5.974，?P=0.015）.?After?treatment，?left?ventricular?mass?index，?myocardial?wall?stress，?left?ventricular?posterior?wall?thickness，?left?ventricular?ejection?fraction，?N-terminal?pro-brain?natriuretic?peptide?（NT-proBNP），?angiotensin?Ⅱ?and?aldosterone?in?study?group?were?significantly?lower?than?those?in?control?group，?and?left?ventricular?remodelling?index，?stroke?volume?and?left?ventricular?end-diastolic?volume?were?significantly?higher?than?those?in?control?group?（P0.05）.?There?was?no?significant?difference?in?adverse?reactions?between?two?groups?（P0.05）.?Conclusion?The?treatment?effect?of?sacubitril?valsartan?in?CHF?patients?is?significant，?which?can?effectively?improve?cardiac?function?indicators，?reverse?ventricular?remodeling，?reduce?serum?NT-proBNP?level，?and?have?fewer?adverse?reactions.

[Key?words]?Chronic?heart?failure;?Sacubitril?valsartan;?N-ter