生津益胃汤治疗胃阴不足证慢性心力衰竭合并胃肠功能障碍的临床研.docx

生津益胃汤治疗胃阴不足证慢性心力衰竭合并胃肠功能障碍的临床研究

马金成雷振东李密密

[摘要]?目的?研究生津益胃湯治疗胃阴不足证慢性心力衰竭（chronic?heart?failure，CHF）合并胃肠功能障碍的临床疗效。方法?选取68例笔者医院收治的胃阴不足证CHF合并胃肠功能障碍患者，在积极治疗心力衰竭基础上，对照组予奥美拉唑肠溶胶囊、多潘立酮片、胰酶肠溶胶囊治疗，试验组予生津益胃汤治疗，对比两组的临床疗效、中医症状量化评分、胃肠功能量化评分及血清胃泌素（gastrin，GAS）、血浆胃动素（motilin，MTL）、白细胞介素（interleukin，IL）-6、肿瘤坏死因子-α（tumor?necrosis?factor-α，TNF-α）水平。结果?试验组的有效率显著高于对照组，差异有统计学意义（χ2=13.73，P0.05）；治疗后，两组患者的胃肠功能障碍量化评分、中医症状量化评分，血清IL-6、TNF-α水平显著低于治疗前，且试验组上述指标均显著低于对照组，差异有统计学意义（P0.05）。两组患者的血清GAS、血浆MTL水平显著高于治疗前，且试验组均显著高于对照组（P0.05）。结论?生津益胃汤对胃阴不足证CHF合并胃肠功能障碍具有明显的疗效，可改善临床表现，调整胃肠激素及炎症因子水平。

[关键词]?生津益胃汤；胃阴不足证；慢性心力衰竭；胃肠功能障碍

[中图分类号]?R256.21??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.11.017

Clinical?study?of?Shengjin?Yiwei?Decoction?in?treating?chronic?heart?failure?complicated?with?gastrointestinal?dysfunction?of?deficiency?of?stomach?Yin

MA?Jincheng1，?LEI?Zhendong1，?LI?Mimi2

1.Department?of?Geriatrics，?Lishui?Hospital?of?Traditional?Chinese?Medicine，?Lishui?323000，?Zhejiang，?China;?2.Department?of?Neurology，?Lishui?Hospital?of?Traditional?Chinese?Medicine，?Lishui?323000，?Zhejiang，?China

[Abstract]?Objective?To?study?the?clinical?effect?of?Shengjin?Yiwei?Decoction?on?chronic?heart?failure（CHF）?complicated?with?gastrointestinal?dysfunction?in?patients?with?deficiency?of?stomach?Yin.?Methods?Totally?68?patients?with?stomach?Yin?deficiency?syndrome?CHF?complicated?with?gastrointestinal?dysfunction?in?our?hospital?were?selected.?On?the?basis?of?active?treatment?of?heart?failure，?the?control?group?was?treated?with?omeprazole?enteric-soluble?capsule，?domperidone?tablet?and?pancrease?enteric-soluble?capsule，?and?the?experimental?group?was?treated?with?Shengjin?Yiwei?Decoction.The?clinical?efficacy?of?the?two?groups?was?compared.traditional?Chinese?medicine?symptom?quantification?score，?gastrointestinal?function?quantification?score，?serum?gastrin（GAS），?plasma?motilin（MTL），?interleukin（IL）-6?and?tumor?necrosis?factor（TNF）-α?levels.?Results?The?effective?rate?of?experimental?group?was?significantly?