普瑞巴林在围术期镇痛应用及其临床意义_骆丽慧.pdf

Chinese Journal of New Drugs 2013,22(8) ·综述· 普瑞巴林在围术期镇痛应用及其临床意义 骆丽慧，冯智英 ? 浙江大学医学院附属第一医院麻醉科，杭州 310003? ［摘要］ 术后急性疼痛可影响患者的预后和转归，甚至演变为慢性疼痛综合征。研究术后有效镇痛的 方案越来越受重视。目前抗惊厥药物如普瑞巴林等在各类神经病理性疼痛中具有良好疗效，在术后急性疼 痛作为辅助药物也同样具有明显临床意义。回顾近年来关于普瑞巴林围术期临床应用的报道，为围术期复 合应用普瑞巴林，以及确定多模式镇痛方案提供一种全新的治疗思路。 ［关键词］ 围术期? 急性疼痛? 慢性疼痛综合征? 抗惊厥药物? 普瑞巴林 ［中图分类号］ R971． 2 ［文献标志码］ A ［文章编号］ 1003 － 3734? 2013? 08 － 0915 － 04 A review of pregabalin in the treatment of post-operative pain ， LUO Li-hui FENG Zhi-ying ? ， Department of Anesthesiology The First Affiliated Hospital of Zhejiang University ， ， ? School of Medicine Hangzhou 310003 China ［ ］ Abstract Postoperative pain could affect the prognosis of patients and the outcomes of the diseases seri- ， ously and even is related to the chronic pain syndrome． More and more attention is paid to multimodal analgesia ， ， for acute pain． Anticonvulsant drug such as pregabalin which used for the treatment of chronic neuropathic pain has been treated as a adjuvant drug for treatment of acute postoperative pain currently． It was demonstrated that pregabalin are efficacious treatments for neuropathic and postsurgical pain． The reviwe will provide new treatment i- deas and strategies for multimodal analgesia for acute pain by this review． ［ ］ ? ? ? ? Key words perioperative acute pain chronic pain syndrome anticonvulsant drugs pregabalin 术后疼痛是机体对疾病本身及手术造成组织损