Tutorial for Proteomics Data Submission - Molecular amp; Cellular 蛋白质组学数据提交-分子与细胞的教程；.pdf

Tutorial for Proteomics Data Submission Katalin F. Medzihradszky Robert J. Chalkley UCSF Why Have Guidelines? • Large-scale proteomics studies create huge amounts of data. • It is impossible/impractical to present all the results. • The function of the guidelines is to: • Provide enough information to be able to explain the experiment. • Provide an assessment of the reliability of the results. • Provide the data that supports the results, particularly those that have the greatest potential for mis-interpretation, so the readers can manually assess the results that are important to them. The Problem • Proteomics experiments are carried out by many different methods, using a variety of instrument types and employing different analysis tools. Hence, many experimental and analysis parameters need to be reported and the parameters required will differ depending on how the experiment was performed and analyzed. Paris Guidelines • The present publication guidelines were created at a meeting in Paris in May 2005 by about 30 key people within the proteomics community, including: • Academic Researchers • Instrument Manufacturers • Search Engine Designers • Journal Representatives • The guidelines are published1 and are on the Molecular and Cellular Proteomics (MCP) website (). • MCP is using these guidelines for reviewing germane submissions. • Other proteomics journals use different guidelines for a variety of reasons. • A large percentage of manuscripts submitted to MCP are initially not compliant with the guidelines. 1Bradshaw RA, Burlingame AL, Carr S and Aebersold R. Mol Cell Proteomics (2006) 5(5):787-8. How Does MCP Help Authors Make their Papers Accept