老年單纯收缩期高血压的动脉弹性功能变化.doc

文章编号：1006 2866（2002）06-0517-03 老年单纯收缩期高血压的动脉弹性功能变化 张维忠，白 煜，丁跃有 （上海第二医科大学附属瑞金医院 上海市高血压研究所，上海200025） Arterial Elastic Function Change in Elderly Patients With Isolated Systolic Hypertension ZHANG Wei-zhong, BAI Yu DING Yue-you (1.Shanghai Institute of Hypertension, Shanghai 200025,China) Abstract Objective To evaluate the elastic function of large and small artery among the health subjects, the patients with the different type of hypertension in the elderly, ie ISH and NISH. Methods Fifty healthy elderly subjects (25 males and 25females, average age 68±5 years) and 84 patients with hypertension (39 males and 45 females, average age 68±5 years) were enrolled, consisting 64 ISH and 20 NISH. Radial arterial pulse wave and arterial elastic index C1 and C2 were measured by DO2020 arterial pulse contour instrument. Results Arterial capacitive compliance (C1) was significantly lower in ISH group (7±2.1ml/mmHg×10) than in NISH group (9.2±3.1ml/mmHg×10), P0.01, and control subjects (12.9±4 ml/mmHg×10), P0.01.However, oscillatory compliance (C2) was similar in ISH and NISH group (2.6±2.2ml/mmHg×100 versus 2.7±2.5ml/mmHg×100,P0.05), both were significantly lower than control group (4.3±2.5ml/mmHg×100,P0.01. No correlation between pulse pressure and artery elastic indexes (C1: r=-0.105,P=0.410;C2: r=-0.203,P=0.108) in the ISH group was found, whereas in the control group an inverse relationship between pulse pressure and the artery elastic indexes was demonstrated (C1 r=-0.627,P0.001;C2: r=-0.389,P0.001. Conclusion Elastic dysfunction in large and small arterial was present in the elderly patients with ISH. Key words: isolated systolic hypertension (ISH) in the elderly; artery elastic function; pulse pressure. 摘要 目的 比较老年正常血压者、单纯性收缩期高血压（ISH）与非单纯性收缩期高血压（NISH）患者的动脉弹性功能，了解不同类型老年高血压大动脉和小动脉弹性的差别。方法 选择50例健康老年人（男女各25例，平均年龄68±5岁）和84例老年高血压病人（男性39例，女性45例，平均年龄68±5岁），其中单纯性收缩期高血压（ISH）64例，非单纯性收缩期高血压（NISI）20例。使用DO2020动脉功能测定仪检测桡动脉脉搏波形和动脉弹性指数C1和C2。 结果 ISH大动脉弹性指数C1（7±2.1ml/mmHg×10）低于NISH