Phakellia属海绵次生代谢产物研究进展.PDF

- 130 - Drug Evaluation Research 第 35 卷 第 2 期 2012 年 4 月 Phakellia 属海绵次生代谢产物研究进展 1, 2 1 2 1 2 曹桂东 ，张红军 ，骆 昉 ，林厚文 ，宋少江 1. 第二军医大学长征医院 药学部，上海 200433 2. 沈阳药科大学 中药学院，辽宁 沈阳 110016 摘 要：海绵是目前海洋天然产物研究中最吸引人的海洋生物之一，海绵中含有丰富的、结构新颖的次生代谢产物，大多数 具有显著的生理活性。Phakellia 属海绵属于寻常海绵纲软海绵目小轴海绵科，种类较多，分布广泛，在国内外得到了广泛 的研究。对近几十年来从Phakellia 属海绵中分离鉴定的次生代谢产物进行了系统的归纳整理，这些化学成分主要包括环肽、 生物碱、聚醚、萜类、甾醇、炔酸等种类，并对其药理活性进行了简单总结，对 Phakellia 属海绵的进一步研究开发具有一 定的借鉴和指导意义。 关键词：海绵；Phakellia ；次生代谢产物；环肽 中图分类号：R282.74 文献标志码：A 文章编号：1674 - 6376 (2012) 02 - 0130 - 06 Research progress on secondary metabolites from marine sponge of genus Phakellia 1, 2 1 2 1 2 CAO Gui-dong , ZHANG Hong-jun , LUO Fang , LIN Hou-wen , SONG Shao-jiang 1. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China 2, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China Abstract: Marine sponge is one of the most attractive marine organism on the research of marine natural products. Sponge contains abundant new secondary metabolites, most of which have significant biological activities. Phakellia spp., belonging to Axinellidae, Halichondrida, Demospongiae, is widely distributed at home and abroad, and it has been widely studied. This paper reviews the progress in the chemical and biological activities of the secondary metabolites from the sponge of genus Phakellia spp. in the past decades. The secondary metabolites mainly include cyclic peptide, alkaloids, polyether, terpenoids, sterols, and acetylenic acids. This paper is meaningful to the further research and development of marine sponge Phakellia spp. Key words: marine sponge; Phakellia ; secondary metabolites; cyclic peptide