白芍总苷对系统性红斑狼疮CD4_T细胞ITGAL基因表达及启动子甲基化修饰的影响.pdf

2012, 37(5) ht p://; ht p:// J Cent South Univ (Med Sci) 463 P P P DOI:10.3969/j.issn.1672-7347.2012.05.006 Effect of total glucosides of peony on expression and DNA methylation status of ITGAL gene in CD4+ T cells of systemic lupus erythematosus ZHAO Ming, LIANG Gongping, LUO Shuangyan, LU Qianjin ( Department of Dermatology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, China) ABSTRACT Objective: To investigate the ef ect of total glucosides of peony (TGP) on expression and DNA methylation status of ITGAL gene (CD11a) in CD4+ T cells from patients with systemic lupus erythematosus (SLE).