cytomegalovirus infection causes an increase of arterial blood pressure巨细胞病毒感染导致增加了动脉血压.pdf

Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure 1¤ 2 3 3 4 5 Jilin Cheng , Qingen Ke , Zhuang Jin , Haibin Wang , Olivier Kocher , James P. Morgan , Jielin 1 1 Zhang *, Clyde S. Crumpacker * 1 Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Division of Allergy, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Cardiovascular Center, Caritas St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America Abstract Cytomegalovirus (CMV) infection is a common infection in adults (seropositive 60–99% globally), and is associated with cardiovascular diseases, in line with risk factors such as hypertension and atherosclerosis. Several viral infections are linked to hypertension, including human herpes virus 8 (HHV-8) and HIV-1. The mechanisms of how viral infection contributes to hypertension or increased blood pressure are not defined. In this report, the role of CMV infection as a cause of increased blood pressure and in forming aortic atherosclerotic plaques is examined. Using in vivo mouse model and in vitro molecular biology analyses, we find that CMV infection alone caused a significant increase in arterial blood pressure (ABp)