Toll样受体在脑损伤中的作用机制及研究进展.pdf

2010 12 23 12 J ed Postgra, Vol. 23, No. 12, December, 2010 # 1319# Toll 李光照,杭春华 [] Toll样受体(Toll-like receptor, TLR)参与宿主抵抗外界致病微生物入侵机体的第一道防线, 在非感染性疾病 与体内相应的内源性配体结合可触发免疫炎性反应在 枢神经系统疾病 , 免疫炎症反应对脑组织有重要的损害作用 TLR在 枢神经系统内广泛表达,脑损伤后各种内源性配体释放, 可与 TLR结合,通过信号级联传导, 参与脑损伤的病理生理 过程 [] Toll; TLR4; TLR2; [] R742 [] A [] 1008-8199(2010) 12-1319-05 A ction m echan ism s of Toll-like recep tors in brain inju ry LIGuang-zhaoreview ing, HANG Chun-hua checking (D epartment of N eurosurgery, N anj ing School of ClinicalM edicine, SouthernM edical University / N anj ing eneral H osp ital of N anjingM ilitary Command, PLA, Nanj ing 210002, Jiangsu, China) [A bstrac t ] Tol-l like receptors (TLR) constitute the first-line defense of the body against the invasion of external pathogenic m icroorganisms and, when combined w ith the corresponding endogenous ligand in non-infectious disease in vivo, can trigger the mi - mune inflammatory response. In central nervous system diseases, mi mune and inflammatory responses inflict serious damage on the brain tissue. TLRs are extensively expressed in the centralnervous system. Brain injury induces the releaseof various endogenous lig- ands, which are combinedwithTLRs via the signal transduction cascadeand involved in thepathophysiologicalprocess ofbrain injury. [ K ey w ord s Toll-like receptor; Toll-like receptor4; Tol-l like receptor2; Brain injury 反应 具有重要作用 0 1 Toll TLR是一类天然免疫受体, 参与宿主对感染性 疾病的第 一道天然防线机体的模式识别受体 [ 1] 自 1997年 edzhitov等 发现第一个与果蝇同 ( pattern recognition receptors, PRR)与病原体进化过 源的人Toll样受体蛋白以来, 至今已在人类和鼠类发 程 保留的病原相关分子模式( pathogen-associated 现有 13种TLR(人类 10种, 鼠类 12种)主要分布