Toll样受体靶向药物的研究进展.pdf

第27卷第4期 生命科学 Vol. 27, No. 4 2015年4月 Chinese Bulletin of Life Sciences Apr., 2015 DOI: 10.13376/j.cbls/2015057 文章编号：1004-0374(2015)04-0439-06 Toll样受体靶向药物的研究进展 钟静静，万岩岩，刁昱文，刘　兵，王竹林，靳广毅，高宁宁* (深圳大学医学部，深圳 518060) Toll 摘　要 ： 样受体是一类进化上高度保守的模式识别受体，通过多种信号传递途径调节免疫系统功能， I Toll 活化后可诱导多个蛋白质家族的表达，包括炎性细胞因子、 型干扰素和趋化因子。 样受体的过度活化 或活化不足均会导致机体功能异常，其与免疫系统疾病、肿瘤发病机制密切相关，是个非常值得开发的新 型治疗靶点。现就对目前已开发Toll 样受体药物进行了研究，对其治疗效果及临床进展做一简要综述，以 期为临床预防和治疗疾病提供参考。 Toll 关键词： 样受体；靶向治疗；激动剂 Q819 R967 A 中图分类号： ； 文献标志码： The research development of Toll-like receptors targeted drugs ZHONG Jing-Jing, WAN Yan-Yan, DIAO Yu-Wen, LIU Bing, WANG Zhu-Lin, JIN Guang-Yi, GAO Ning-Ning* (School of Medicine, Shenzhen University, Shenzhen 518060, China) Abstract: Toll-like receptors are highly conserved pattern recognition receptors (PRRs). The activation of Toll can regulate the systematic immunological function and induce the expression of many protein families, including inflammation cytokines, class I interferon and chemokines. The overexpression or insufficient of TLR activation would lead to the systematic disorder. TLRs are novel potential therapy targets based on their importance in immunological disease and tumor development mechanism. We summarized the effects and clinic progresses of TLRs targeted drugs for clinical prevention and therapy. Key words: Toll-like receptors; targeted therapeutics; agonist B1 HMGB1 β- [4-5] 天然免疫系统通过机体自身的模式识别受体 迁移率族蛋白 ( ) 和 防御素 。跨膜