NRF2的抗氧化作用.pdf

Acta Pharmacol Sin 2007 Sep; 28 (9): 1409 1421 Invited review Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models1 Ki Han KWON2,3, Avantika BARVE2,4, Siwang YU2,3, Mou-Tuan HUANG2,5, Ah-Ng Tony KONG2,3,6 2 Center f or Cancer P revention R esearch, 3D ep artment of Pharmaceutics, 4 Graduate Prog ram in P harmaceutical Science, 5Susan L ehman Cullman Laboratory f or Cancer Research, D ep artment of Chemical B iology, Ernest M ario School of Pharmacy , Rutg ers, The State University of New Je rsey, P iscataway, NJ 08854, USA Key words Abstract chemoprevention; dietary cancer chemopre- Recent studies have strongly indicated that certain daily-consumed dietary v ent iv e comp ou nd s ; n u clear fa ctor E 2- phytochemicals could have cancer protective effects against transgenic mice can- r elated factor 2 ; nu clear factor -k app aB; act iv at or p r ot ein - 1; m it og en -a c ti v at ed cer models and cancers mediated by carcinogens, irradiations and carcinogenic protein kinases metabolites derived from exogenous or endogenous sources. The cancer-protec- tive effects elicited by these dietary compounds are believed to be due at least in 1 This study was supported in part by Institu- part to the induction of cellular defense systems including the detoxifying and tional Fund s and by RO 1-CA094828, RO 1- antioxidant enzymes system, as well as the inhibition of anti-inflammatory and CA 0 9 2 5 15 , R O1- CA 0 7 3 6 74 an d R 0 1- anti-cell growth signaling pathways culminating in cell cycle arrest and/or cell- CA1 18947 to Dr Ah-Ng Tony KONG from the N ational In stitutes of Health (NIH). death. In this review, we summarize the potential mechanisms including the modu- 6