combined treatment with an oncolytic adenovirus and antitumor activity of vincristine against retinoblastoma cells结合治疗溶瘤腺病毒和长春新碱对视网膜母细胞瘤细胞的抗肿瘤活性.pdf

Int. J. Mol. Sci. 2012, 13, 10736-10749; doi:10.3390/ijms130910736 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Combined Treatment with an Oncolytic Adenovirus and Antitumor Activity of Vincristine against Retinoblastoma Cells Xin Song 1,†, Haibo Wang 2,†, Renbing Jia 1, Biyun Cun 1, Xiaoping Zhao 1, Yixiong Zhou 1, Xiaofang Xu 1, Guanxiang Qian 2, Shengfang Ge 1,2,* and Xianqun Fan 1,* 1 Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; E-Mails: songxin0521@ (X.S.); jrb6@ (R.J.); catherine1_2_3@ 163.com (B.C.); zxp0856@ (X.Z.); zhouyixiong21@ (Y.Z.); xuxu0139@ (X.X.) 2 Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; E-Mails: wanghaibode@ (H.W.); qiangx@ (G.Q.) † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: geshengfang@ (S.G.); fanxq@ (X.F.); Tel.: +86-021-6313-5606 (S.G.); +86-021-2327-1699 (ext. 5586) (X.F.); Fax: +86-021-6313-7148 (S.G.); +86-021-6313-7148 (X.F.). Received: 7 June 2012; in revised form: 21 August 2012 / Accepted: 22 August 2012 / Published: 27 August 2012 Abstract: Treatment trends of retinoblastoma (RB) have gradually evolved from eye enucleation and external radiation to local treatment. Combined treatment with an