antitumor activity of rapamycin in a phase i trial for patients with recurrent pten-deficient glioblastoma在第一阶段试验中雷帕霉素的抗肿瘤活性pten-deficient复发胶质母细胞瘤患者.pdf

PLoS MEDICINE Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma 1[ 2[¤ 1[ 3 2 2 4 Tim F. Cloughesy , Koji Yoshimoto , Phioanh Nghiemphu , Kevin Brown , Julie Dang , Shaojun Zhu , Teli Hsueh , 4 5 3 6 6 6 6 1 Yinan Chen , Wei Wang , David Youngkin , Linda Liau , Neil Martin , Don Becker , Marvin Bergsneider , Albert Lai , 7 5 5 3 8 2,4[ 4[ Richard Green , Tom Oglesby , Michael Koleto , Jeff Trent , Steve Horvath , Paul S. Mischel , Ingo K. Mellinghoff , 9[* Charles L. Sawyers 1 Department of Neurology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 2 Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 3 Translational Genomics Research Institute, Phoenix, Arizona, United States of America, 4 Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 5 Taylor