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and FAP are both associated with familial colon HNPCC和FAP都与家族性结肠癌相关ppt课件.ppt

发布:2018-07-27约小于1千字共16页下载文档
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HNPCC and FAP are both associated with familial colon cancer but differ in many aspects. Describe the similarities and differences between these conditions. How does MYH polyposis differ from both?;Essay plan;Colorectal cancer;Diagnosis of hereditary colorectal cancer;Cancer predisposition;Inheritance;Gene/s involved;Mismatch repair genes (MMR) e.g. MLH1, MSH2, MSH6, PMS2;Tumour suppressor genes e.g. APC;Microsatellite instability (MSI) vs chromosomal instability (CIN);Types of mutation;Testing methods;Surveillance;MYH polyposis (differences between this and HNPCC FAP);MYH polyposis: Base Excision Repair (BER);References
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