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comparison of life history characteristics of the genetically modified ox513a line and a wild type strain of aedes aegypti比较转基因ox513a的生活史特征线和埃及伊蚊的野生型菌株.pdf

发布:2017-09-14约5.07万字共7页下载文档
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Comparison of Life History Characteristics of the Genetically Modified OX513A Line and a Wild Type Strain of Aedes aegypti 1,2 2 2,3 1 Irka Bargielowski *, Derric Nimmo , Luke Alphey *, Jacob C. Koella 1 Division of Biology, Imperial College London, London, United Kingdom, 2 Oxitec Limited, Oxford, United Kingdom, 3 Department of Zoology, University of Oxford, Oxford, United Kingdom Abstract The idea of implementing genetics-based insect control strategies modelled on the traditional SIT (Sterile Insect Technique), such as RIDL (Release of Insects carrying a Dominant Lethal), is becoming increasingly popular. In this paper, we compare a genetically modified line of Aedes aegypti carrying a tetracycline repressible, lethal positive feedback system (OX513A) with a genetically similar, unmodified counterpart and their respective responses to increasing larval rearing density using a constant amount of food per larva. The parameters that we examined were larval mortality, developmental rate (i.e., time to pupation), adult size and longevity. Analysis revealed some statistically significant differences between the life history traits we examined. The genetically modified OX513A line overall showed 5% lower larval survival as well as reduced adult longevity (20 vs 24 days mean lifespan) compared to the unmodified line. Furthermore, the OX513A line pupated about one day sooner, which could be advantageous in mass-rearing, but produced somewhat smaller adults than the unmodified line; this effect was more pronounced in females than in males. Increasing the larval rearing density delayed pupation, decreased adult longevity and reduced adult size in both lines. While the delay in pupation a
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