contribution of natural inhibitors to the understanding of the pi3kpdk1pkb pathway in the insulin-mediated intracellular signaling cascade贡献的天然抑制剂在insulin-mediated pi3kpdk1pkb途径的理解细胞内的信号级联.pdf

Int. J. Mol. Sci. 2008, 9, 2217-2230; DOI: 10.3390/ijms9112217 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms/ Review Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade Jae Youl Cho 1 and Jongsun Park 2,* 1 School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. E-Mail: jaecho@kangwon.ac.kr 2 Department of Pharmacology, Cell Signaling Laboratory, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301-131, South Korea * Author to whom correspondence should be addressed; E-Mail: insulin@cnu.ac.kr; Tel. +82-42-580-8252; Fax: +82-42-585-6627 Received: 15 July 2008; in revised form: 8 November 2008 / Accepted: 12 November 2008 / Published: 12 November 2008 Abstract: The critical initial steps in insulin action include phosphorylation of adapter proteins and activation of phosphatidylinositol 3-kinase (PI3K). One of important components in this process is a protein called Akt/protein kinase B (PKB). The work of numerous different researchers indicates a role of PKB in regulating insulin-stimulated glucose uptake. The crucial role of lipid second messe