the application of microencapsulation techniques in the treatment of endodontic and periodontal diseases微型胶囊的应用技术治疗牙髓学的和牙周疾病.pdf

Pharmaceutics 2011, 3, 538-571; doi:10.3390/pharmaceutics3030538 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases Asteria Luzardo Álvarez 1,*, Francisco Otero Espinar 2 and José Blanco Méndez 1,2 1 Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Ciencias, Universidad de Santiago de Compostela, 27002 Lugo, Spain; E-Mail: jose.blanco.mendez@usc.es 2 Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain; E-Mail: francisco.otero@usc.es * Author to whom correspondence should be addressed; E-Mail: asteriam.luzardo@usc.es; Tel: 0034-9828-24151; Fax: 0034-9822-85872. Received: 5 July 2011; in revised form: 9 August 2011 / Accepted: 24 August 2011 / Published: 26 August 2011 Abstract: In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained drug release, high antimicrobial activity and low systemic side effects. Microparticles made from biodegradable polymers have been reported to be an effective means of delivering antibacterial drugs in endodontic and periodontal therapy. The aim of this review article is to assess recent therapeutic strategies in which biocompatible microparticles are used for effective