spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases脾酪氨酸激酶抑制治疗自身免疫、过敏和autoinflammatory疾病.pdf

Pamuk and Tsokos Arthritis Research Therapy 2010, 12:222 /content/12/6/222 R E V I E W Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinl ammatory diseases 1,2 1 Omer N Pamuk and George C Tsokos* Syk plays an important role in signal transduction Abstract initiated by the classic immunoreceptors, including B-cell Spleen tyrosine kinase (Syk) is involved in the receptors (BCRs), Fc receptors, and the activating natural development of the adaptive immune system and has killer receptors [3,6,7]. Syk is associated mainly with been recognized as being important in the function of ITAM (immunoreceptor tyrosine-based activation motif)- additional cell types, including platelets, phagocytes, dependent pathways and aff ects early development and i broblasts, and osteoclasts, and in the generation activation of B cells, mast cell degranulation, neutrophil of the inl ammasome. Preclinical studies presented and macrophage phagocytosis, and platelet activation compelling evidence that Syk inhibition may have [1,3,4]. Functional abnormalities of these cells are therapeutic value in the treatment of rheumatoid invariably associated with both autoimmune and allergic arthritis and other forms of arthritis, systemic lupus diseases. Although there have been many exciting erythematosus, autoimmune cytopenias, and allergic develop ments in the treatment of these