t-bu2sif-derivatized d2-receptor ligands the first sifa-containing small molecule radiotracers for target-specific pet-imaging第一sifa-containing t-bu2sif-derivatized d2-receptor配体小分子放射性示踪剂有针对性的pet成像.pdf

Molecules 2011, 16, 7458-7479; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article t-Bu SiF-Derivatized D -Receptor Ligands: 2 2 The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging 1 2 1 3 Ljuba Iovkova-Berends , Carmen Wängler , Thomas Zöller , Georg Höfner , 3 4 2 5 Klaus Theodor Wanner , Christian Rensch , Peter Bartenstein , Alexey Kostikov , Ralf Schirrmacher 5, Klaus Jurkschat 1,* and Björn Wängler 2,* 1 Department of Inorganic Chemistry II, Faculty of Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany 2 Department of Nuclear Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany 3 Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-University, Butenandtstr. 7, 81377 Munich, Germany 4 GE Global Research, 85748 Garching, Germany 5 McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University St., Montreal H3A 2B4, QC, Canada * Authors to whom correspondence should be addressed; E-Mails: klaus.jurkschat@uni-dortmund.de (K.J.); bjoern.waengler@med.uni-muenchen.de (B.W.); Tel.: +49-231-755-3800 (K.J.); +49-89-7095-7543 (B.W.); Fax: +49-231-755-5048 (K.J.); +49-89-7095-4648 (B.W.). Received: 28 July 2011; in revised form: 19 Aug