the combination of in vivo 124i-pet and ct small animal imaging for evaluation of thyroid physiology and dosimetry体内的结合124我抚摸和ct小动物成像评价甲状腺生理和剂量测定法.pdf

Diagnostics 2012, 2, 10-22; doi:10.3390/diagnostics2020010 OPEN ACCESS diagnostics ISSN 2075-4418 /journal/diagnostics/ Article 124 The Combination of In vivo I-PET and CT Small Animal Imaging for Evaluation of Thyroid Physiology and Dosimetry Henrik H. El-Ali 1,2,*, Martin Eckerwall 3, Dorthe Skovgaard 1,2, Erik Larsson 3, Sven-Erik Strand 3 and Andreas Kjaer 1,2 1 Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark; E-Mails: dskovgaard@ (D.S.); akjaer@sund.ku.dk (A.K.) 2 Department of Clinical Physiology, Nuclear Medicine PET, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark 3 Medical Radiation Physics, Department of Clinical Sciences, University of Lund, Lund SE-221 85, Sweden; E-Mails: martin.eckerwall@ (M.E.); erik.larsoon@med.lu.se (E.L.); sven-erik.strand@med.lu.se (S.-E.S.) * Author to whom correspondence should be addressed; E-Mail: helali@sund.ku.dk; Tel.: +45-3532-7521; Fax: +45-3532-7546. Received: 27 April 2012; in revised form: 24 May 2012 / Accepted: 29 May 2012 / Published: 5 June 2012 Abstract: Objective: A thyroid rat model combining functional and anatomical information would be of great benefit for better modeling of thyroid physiology and for absorbed dose calculations. Our aim was to show that 124I-PET and CT small animal imaging are useful as a combined model for studying thyroid physiology and dose calculation. Methods :