蛋白质磷酸化位点的识别蛋白质磷酸化位点的识别.pdf

JOU RNAL OF INNER MONGOLIA 30 2 UNIVERSITY OF TECHNOLOGY Vol. 30 No . 2 2011 : 1001- 5167( 2011) 03- 0081- 05 * 白海艳, 吕 军, 张 颖, 计美珍, 秦丹丹 ( 010051) : , , CK2, PKA PKC , , , - ( Jensen- Shannon Divergence, JSD) , , CK2, PKA PKC 7- fold , 90% , 90% 86% , : , - , : Q61 : A 0 引 言 , , , , , , , , , , , 30% - 50% [ 1] , 5%, , , , , AT P GT P , , ( serine, S) , ( threonine, T ) ( tyrosine, Y) ( protein kinase, PK) , , , , , Edman , , , Edman : 2011- 01- 19 * : ( 2010BS010 ) : , , : , Email: lujun@ imut. edu. cn 2 109 [ 2] , : , ; , ; , , 1999 , Blom[ 3] , , , , ( Artificial [ 3, ] [ 5, 6] [ 7] Neural Netw ork, ANN) , ( Support Vector M achine, SVM) , K , ( Hidden M arkov Model, HM M) [ 8] , ( logistic regression models) [ 9] , ( position- specific scoring matrix , PSSM) [ 10] , ( Information- Entropy) [ 11] , ( Bayesian decision theory, BDT) [ 12] , ( w eighted voting) [ 13] 2008 Zhang ( Increment of Diversity w ith Quadratic Discriminant analysis, IDQD) [ 1 ] [ 15] Basu 10 , , ( ) , , , , - (Jensen- Shannon Divergence w ith Quadratic Discriminant analysis, JSDQD) , 1 材料和方法 1. 1 [ 1 ] Phospho. ELM 6. 0 [ 16] , CK2( casein kinase 2) , PKA ( protein kinase A ) PKC