targeting vascular nadph oxidase 1 blocks tumor angiogenesis through a pparα mediated mechanism针对血管nadph氧化酶1块通过pparα介导肿瘤血管生成机制.pdf

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARa Mediated Mechanism 1 1 1 ´ 1,2 1 Sarah Garrido-Urbani , Stephane Jemelin , Christine Deffert , Stephanie Carnesecchi , Olivier Basset , ´ 3 3 3 4 5 6 Cedric Szyndralewiez , Freddy Heitz , Patrick Page , Xavier Montet , Liliane Michalik , Jack Arbiser , ¨ 7 1 1 Curzio Ruegg , Karl Heinz Krause , Beat Imhof * ´ ´ 1 Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland, 2 Department of Pediatrics, Centre Medical ´ Universitaire, University of Geneva, Geneva, Switzerland, 3 GenKyoTex S.A., Geneva, Switzerland, 4 Department of Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland, 5 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland, 6 Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, United States of America, 7 Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland Abstract Reactive oxygen species, ROS, are regulators of endothelial cell migration,