targeting the lactate transporter mct1 in endothelial cells inhibits lactate-induced hif-1 activation and tumor angiogenesis针对乳酸转运体在内皮细胞抑制mct1 lactate-induced hif-1激活和肿瘤血管生成.pdf

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis 1,2 1 1 ´ ´ ´ 1 1 Pierre Sonveaux *, Tamara Copetti , Christophe J. De Saedeleer , Frederique Vegran , Julien Verrax , 2 4 1 3 ´ 1 3 Kelly M. Kennedy , Eui Jung Moon , Suveera Dhup , Pierre Danhier , Franc¸oise Frerart , Bernard Gallez , 5 6 2,4. 1. Anthony Ribeiro , Carine Michiels , Mark W. Dewhirst , Olivier Feron ´ 1 Pole of Pharmacology, Institute of Experimental and Clinical Research (IREC), Universite catholique de Louvain (UCL), Brussels, Belgium, 2 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, United States of America, 3 Nuclear Magnetic Resonance Research Group, Louvain Drug Research ´ Institute (LDRI), Universite catholique de Louvain (UCL), Brussels, Belgium, 4 Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America, 5 Department of Radiology and Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, 6 Laboratory of Biochemistry and Cellular Biology, University of Namur (FUNDP), Namur, Belgium Abstract Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion