sirt1 regulates insulin secretion by repressing ucp2 in pancreatic β cellssirt1调节胰岛素分泌抑制ucp2的胰腺β细胞.pdf

PLoS BIOLOGY Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells 1*¤ 1[ 2[ 1[ 3 4 Laura Bordone , Maria Carla Motta , Frederic Picard , Ashley Robinson , Ulupi S. Jhala , Javier Apfeld , 4 5 5 6 7 7 Thomas McDonagh , Madeleine Lemieux , Michael McBurney , Akos Szilvasi , Erin J. Easlon , Su-Ju Lin , 1* Leonard Guarente ´ 1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 2 Laval Hospital Research Center, Quebec City, ´ Quebec, Canada, 3 The Whittier Institute for Diabetes, University of California San Diego, La Jolla, California, United States of America, 4 Elixir Pharmaceuticals, Cambridge, Massachusetts, United States of America, 5 Department of Medicine and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, and the Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada, 6 Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America, 7 Center for Genetics and Development, and Section of Microbiology, University of California Davis, Davis, California, United States of America Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway