structural basis for differential neutralization of ebolavirusesebolaviruses中和差结构依据.pdf

Viruses 2012, 4, 447-470; doi:10.3390/v4040447 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Article Structural Basis for Differential Neutralization of Ebolaviruses Shridhar Bale 1,†, Joao M. Dias 1, †, ††, Marnie L. Fusco 1, Takao Hashiguchi 1, 2 3 4 3 3 Anthony C. Wong , Tong Liu , Ana I. Keuhne , Sheng Li , Virgil L. Woods, Jr. , Kartik Chandran 2, John M. Dye 4 and Erica Ollmann Saphire 1,5,* 1 Dept. of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; E-Mails: sbale@ (S.B.); jmcndias@ (J.M.D.); mhavert@ (M.L.F.); takaoh@ (T.H.) 2 Dept. of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; E-Mails: anthony.wong@ (A.C.W.); kartik.chandran@ (K.C.) 3 Dept. of Medicine, University of California San Diego, La Jolla, CA 92093, USA; E-Mails: toliu@ (T.L.); s4li@ (S.L.); vwoods@ (V.L.W.) 4 Virology Division, United States Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA; E-Mails: ana.kuehne@ (A.I.K.); john.m.dye1@ (J.M.D.) 5 The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA † These authors contributed equally to this work. †† Present address: Heptares Therapeutics, Welwyn Garden City, Hertsfordshire, UK AL7 3AX. * Author to whom correspondence should be addressed; E-Mail: