unexpected course of nonlinear cardiac interbeat interval dynamics during childhood and adolescence意想不到的心脏interbeat区间非线性动力学在童年和青春期.pdf

Unexpected Course of Nonlinear Cardiac Interbeat Interval Dynamics during Childhood and Adolescence 1,2 3 ¨ 1,2 ¨ 1,2,4 5 Dirk Cysarz *, Maijana Linhard , Friedrich Edelhauser , Alfred Langler , Peter Van Leeuwen , ¨ 3, Georg Seifert3 Gunter Henze 1 Integrated Curriculum for Anthroposophic Medicine, University of Witten/Herdecke, Witten, Germany, 2 Chair for Theory of Medicine, Integrative and Anthroposophic Medicine, University of Witten/Herdecke, Witten, Germany, 3 Department of Pediatric Oncology/Hematology, Otto-Heubner-Center for Pediatric and Adolescent Medicine, ´ ¨ Charite Universitatsmedizin, Berlin, Germany, 4 Department of Pediatric and Adolescent Medicine, Gemeinschaftskrankenhaus, Herdecke, Germany, 5 Department of Radiology and Microtherapy, University of Witten/Herdecke, Bochum, Germany Abstract The fluctuations of the cardiac interbeat series contain rich information because they reflect variations of other functions on different time scales (e.g., respiration or blood pressure control). Nonlinear measures such as complexity and fractal scaling properties derived from 24 h heart rate dynamics of healthy subjects vary from childhood to old age. In this study, the age- related variations during childhood and adolescence were addressed. In particular, the cardiac interbeat interval series was quantified with respect to complexity and fractal scaling properties. The R-R interval series of 409 healthy children and adolescents (age range: 1 to 22 years, 220 females) was analyzed with respect to complexity (Approximate Entropy, ApEn) and fractal scaling properties on three time scales: long-term (slope b of the power spectrum, log powe