微生物精品教学（汕头大学）抗感染免疫ppt课件.ppt

Anti-Infection Immunity抗感染免疫;Outline; Nonspecific immunity Specific immunity ;Specific Immunity;Innate Immunity Acquired immunity;Nonspecific Immunity;1.Mechanism of non-specific immunity ;Barrier Structure;Use other microbes as guard-dogs that kill intruders ;;Phagocytosis;;中性粒细胞吞噬脑膜炎奈瑟菌;Step One: Chemotaxis;Step Two: Contact;Step Three: Phagocytosis/ Pinocytosis;Step Four: Digest Dissolution ;;各类吞噬细胞吞噬杀菌特性：;吞噬细胞表面受体： ①模式识别受体（甘露糖受体MR、清道夫受体SR、Toll样受体TLR）； ②病原体相关模式分子（pathogen associated molecular patterns,PAMP） ③调理性受体: IgGFcR、C3bR/ C4bR ④细胞因子受体 吞噬细胞的功能： ①清除杀伤病原体（氧依赖/非依赖途径） ②参与和促进炎症反应 ③杀伤靶细胞 ④加工、提呈Ag ⑤免疫调节 ;NK细胞;;;?? T cell;多聚C9形成的膜攻击复合物;MAC的电镜结果;; G G G G o o o o M M M M o b o b o b o b G G G G o o o o M M M M o b o b o b o b G G G G o o o o M M M M ; ;binds to surface receptor of an neighboring cells; ⑷ Feature of antiviral activity ;Pathogen-associated molecular patterns, PAMP Pattern recognition receptors, PRR Toll-like receptors, TLR;Pathogen-associated molecular patterns;2.Mechanism of specific immunity;Mucosal immunity;;DC’s function in Mucosal immunity;T cell;Humoral immunity(HI);Cell-mediated immunity (CMI) or cellular immunity;;毒力;Mechanism;1.Immunity of anti-extracellular bacterial infection;2.Immunity of anti-intracellular bacteri