structural and functional characterization of two alternative splicing variants of mouse endothelial cell-specific chemotaxis regulator (ecscr)结构和功能特性的两个可变剪接变异的老鼠内皮特异性趋化性监管机构(ecscr).pdf

Int. J. Mol. Sci. 2012, 13, 4920-4936; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Structural and Functional Characterization of Two Alternative Splicing Variants of Mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR) Wen Wu 1,2,3,†, Chunwei Shi 1, Fanxin Ma 1, James Balducci 1, Hanju Huang 3, Hong-Long Ji 4, Yongchang Chang 2 and Yao Huang 1,* 1 Department of Obstetrics and Gynecology, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85004, USA; E-Mails: wuwe (W.W.); scwoycj@ (C.S.); fanxin.ma@ (F.M.); james.balducci@ (J.B.) 2 Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85013, USA; E-Mail: yongchang.chang@ 3 Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; E-Mail: juguangying@ 4 Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA; E-Mail: HongLong.Ji@ † Current address: Microbiology Laboratory, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. * Author to whom correspondence should be addressed; E-Mail: yhuang@ or Yao.Huang@DignityH; Tel.: +1-602-406-8312; Fax: +1-602-406-4 172. Received: 8 February 2012; in revised form: 19 March 2012 / Accepted: 20 March 2012 / Published: 19 April 2012 Abstract: Endothelial cells (ECs) that line the lumen of blood vessels are i