the alternative epaccamp pathway and the mapk pathway mediate hcg induction of leptin in placental cells替代epaccamp通路和mapk途径调解hcg感应胎盘瘦素的细胞.pdf

The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells ´ 1 ´ ´ 2 3 ´ ˜ 4 Julieta Lorena Maymo , Antonio Perez Perez , Bernardo Maskin , Jose Luis Duenas , 1,5 ´ ´ 2 1 Juan Carlos Calvo , Vıctor Sanchez Margalet , Cecilia Laura Varone * ´ ´ ´ 1 Departamento de Quımica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina, 2 Departamento de Bioquımica ´ ´ ˜ Medica y Biologıa Molecular. Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Espana, 3 Hospital Nacional Profesor Alejandro ´ ˜ ´ Posadas, Buenos Aires, Argentina, 4 Servicio de Ginecologıa y Obstetricia, Hospital Universitario Virgen Macarena, Sevilla, Espana, 5 Instituto de Biologıa y Medicina Experimental (IBYME), Buenos Aires, Argentina Abstract Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces