singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo奇异值decomposition-based回归确定体内内源性信号通路的激活.pdf

Volume 9, Issue 12, Article R180et al.Liu2008 Open Access Method Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo *† * * * Zhandong Liu , Min Wang , James V Alvarez , Megan E Bonney , Chien- chung Chen* * * ‡ , Celina DCruz , Tien-chi Pan , Mahlet G Tadesse and Lewis A Chodosh*† Addresses: *Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, BRB II/ III 616, Philadelphia, PA 19104, USA. †Genomics and Computational Biology Graduate Group, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA. ‡Department of Mathematics, Georgetown University, 2115 G Street NW, Washington, DC 20057, USA. Correspondence: Lewis A Chodosh. Email: chodosh@ Published: 18 December 2008 Received: 23 October 2008 Accepted: 18 December 2008 Genome Biology 2008, 9:R180 (doi:10.1186/gb-2008-9-12-r180) The electronic version of this article is the complete one and can be found online at /2008/9/12/R180 © 2008 Liu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pathway cross-talk./pSVD regression to study cross-talkpSingular value decomposition regression can detect the activation of endogenous signaling pathway