孟鲁司特纳治疗小儿咳嗽变异性哮喘临床探讨.doc

孟鲁司特纳治疗小儿咳嗽变异性哮喘临床探讨 　　[摘要] 目的 探讨孟鲁司特纳治疗小儿咳嗽变异性哮喘的临床效果。方法 将就诊于该院的75例咳嗽变异性哮喘患儿按照随机数字表法分为对照组37例和观察组38例。对照组患儿单纯给予沙丁胺醇0.25 mL雾化吸入；观察组患者则联合给予孟鲁司特钠咀嚼片口服，连续治疗2个月。观察患儿咳嗽的缓解情况，计算临床治疗的有效率；记录两组患儿咳嗽的消失时间；检测患儿血清炎性细胞因子水平的变化情况，随访3个月观察复发率。结果 观察组患儿的有效率92.1%明显高于对照组的有效率73%（P0.05）。结论 孟鲁司特纳治疗 CVA疗效确切，能有效缩短病程，抗炎作用明显，值得临床推广。 　　[关键词] 孟鲁司特纳；小儿咳嗽变异性哮喘；临床研究 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-0742（2015）05（a）-0129-03 　　Clinical Observation on Treating Children Cough Variant Asthma with Montelukast 　　YANG Fei 　　Pediatrics Department of Yanan Hospital Affiliated to KunMing Medical University 650051 China 　　[Abstract] Objective To investigate the clinical efficacy of treating Children cough variant asthma with montelukast. Methods 75 Cough Variant Asthma with Montelukast Children were randomly divided into a control group of 37cases and an observation group of 38cases. Patients in the control group were treated with 0.25 mL salbutamol for aerosol inhalation，2times/day，7-10 days for a course； while patients in the observation group were treated with montelukast sodium chewable tablets， 1time/day，2 months for treatment. We observed the improvement of cough symptom and calculated the effective clinical treatment； We recorded the disappearance time of cough and tested the level change of serum inflammatory cytokines. We observed the recurrence rate follow-up of 3 months. Results The efficiency for patients in the observation group is92.1%， which was higher than that in the control group 73%（P0.05）. Conclusion Treating Children cough variant asthma with montelukast has definite curative effect. The therapy can effectively shorten the duration of symptoms， which has a significant anti-inflammatory effect， is worthy of further research and development. 　　[Key words] Montelukast；Children Cough Variant Asthma；Clinical Observation 　　小儿咳嗽性哮喘又称咳嗽变异性哮喘，是指以慢性咳嗽为主或惟一临床表现的一种特殊类型哮喘，以气道高反应性及炎症为主要特征[1-2]。患儿多见刺激性咳嗽，发生在夜间或凌晨，因此，往往被误诊为支气管炎，误以抗生素治之。可见，其正确辨治是儿科临床研究的重要靶点。该研究长期以来注重对此病的观察，并且进行了多种药物的疗效比较试验，该研究研