孟鲁司特钠联合硫酸沙丁胺醇气雾剂万托林雾化吸入在治疗小儿咳嗽变异性哮喘临床疗效分析.doc

孟鲁司特钠联合硫酸沙丁胺醇气雾剂万托林雾化吸入在治疗小儿咳嗽变异性哮喘临床疗效分析 　　[摘要] 目的 探讨孟鲁司特钠联合硫酸沙丁胺醇气雾剂（万托林）雾化吸入在治疗小儿咳嗽变异性哮喘的临床疗效。方法 采用随机数字表法将我院60例咳嗽变异性哮喘患儿分为为两组，其中对照组采用常规万托林雾化吸入进行治疗，实验组采用孟鲁司特钠联合万托林雾化吸入经行治疗，观察并比较两组患儿经过治疗后的临床效果。 结果 两组患儿经过治疗后，实验组总有效率（96.67%）明显高于对照组总有效率（70.00%），实验组患儿应用孟鲁司特钠联合硫酸沙丁胺醇气雾剂雾化吸入治疗后咳嗽缓解时间和住院时间（2.85±0.81，5.26±0.80）d明显短于对照组（5.31±1.42，10.35±2.23）d （t=2.649、2.448，P=0.018、0.029）；实验组患儿最大呼气峰流速（1.57±0.52）L/min明显优于对照组（1.25±0.38）L/min（t=2.317，P=0.033），差异有统计学意义（P0.05）。 结论 孟鲁司特钠联合万托林雾化吸入对咳嗽变异性哮喘患儿具有积极作用，提高临床总有效率，改善肺功能，安全、有效，应该在临床上广泛应用。 　　[关键词] 孟鲁司特钠；硫酸沙丁胺醇气雾剂；雾化吸入；小儿咳嗽变异性哮喘 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 2095-0616（2016）01-74-04 　　[Abstract] Objective To investigate the clinical efficacy of montelukast sodium combined with sulphate aerosol albuterol （Ventolin） inhalation in the treatment of children with cough variant asthma. Methods by a random number table method in our hospital 60 cases of children with cough variant asthma were divided into two groups. The control group was given conventional Ventolin inhalation treatment， and the experimental group was treated montelukast sodium combined with Ventolin inhalation therapy， and clinical effects were observed and compared in two groups of children after treatment. Results After treatment the total efficiency rate of the experimental group （96.67%） was significantly higher than the control group （70.00%）. In the experimental group the elapsed time of wheezing and lungs wheeze improved （2.85 ± 0.81， 5.26 ± 0.80） d was significantly shorter than the control group （5.31±1.42， 10.35±2.23） d（t=2.649，2.448，P=0.018，0.029）； the children in the experimental group peak expiratory flow rate （1.57±0.52） L / min was significantly better than the control group （1.25±0.38） L / min（t=2.317，P=0.033）， and there was significant difference（P0.05）. Conclusion Montelukast combined with Ventolin inhalation treatment of cough variant asthma in children has a positive role in enhancing the overall clinical efficiency， improve lung function， safe and effec