colonic biopsies to assess the neuropathology of parkinsons disease and its relationship with symptoms结肠活检评估帕金森病的神经病理学及其与症状之间的关系.pdf

Colonic Biopsies to Assess the Neuropathology of Parkinson’s Disease and Its Relationship with Symptoms 1,2,3,4 . 1,4,6 . 1,2,3,6 Thibaud Lebouvier * , Michel Neunlist * , Stanislas Bruley des Varannes , Emmanuel 1,2,3,6 2 7 1,4 1,4 Coron , Anne Drouard , Jean-Michel N’Guyen , Tanguy Chaumette , Maddalena Tasselli , ´ 1,4, Mathurin Flamand1,2,3,6, Jean-Paul Galmiche1,2,3,6, Philippe Damier2,3,5, Pascal Sebastien Paillusson Derkinderen1,2,3,5,6* ´ ´ ´ 1 UMR 913, Inserm, Nantes, France, 2 CIC-04, Inserm, Nantes, France, 3 UFR Medecine, Universite de Nantes, Nantes, France, 4 UFR Sciences et Techniques, Universite de ˆ Nantes, Nantes, France, 5 Service de Neurologie, CHU Nantes, Nantes, France, 6 Institut des Maladies de l’Appareil Digestif (IMAD), CHU Nantes, Nantes, France, 7 Pole ´ ´ ´ d’Information Medicale, Evaluation et Sante Publique (PIMESP), CHU Nantes, Nantes, France Abstract Background: The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson’s disease (PD) patients. The aims of the present research were to use