arcuate fasciculus abnormalities and their relationship with psychotic symptoms in schizophrenia弓状纤维束异常和精神病症状的精神分裂症的关系.pdf

Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia 1 1,2,3 4 4 Muhammad Farid Abdul-Rahman , Anqi Qiu *, Puay San Woon , Carissa Kuswanto , Simon L. Collinson4,5, Kang Sim4,6 1 Division of Bioengineering, National University of Singapore, Singapore, 2 Clinical Imaging Research Center, National University of Singapore, Singapore, 3 Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, 4 Research Division, Institute of Mental Health, Singapore, 5 Department of Psychology, Institute of Mental Health, Singapore, 6 Department of General Psychiatry, National University of Singapore, Singapore Abstract Disruption of fronto-temporal connections involving the arcuate fasciculus (AF) may underlie language processing anomalies and psychotic features such as auditory hallucinations in schizophrenia. No study to date has specifically investigated abnormalities of white matter integrity at particular loci along the AF as well as its regional lateralization in schizophrenia. We examined white matter changes (fractional anisotropy (FA), axial diffusivity (AD), asymmetry indices) along the whole extent of the AF and their relationship with psychotic symptoms in 32 males with schizophrenia and 44 healthy males. Large deformation diffeomorphic metric mapping and Fiber Assignment Continuous Tracking were employed to characterize FA and AD along the geometric curve of the AF. Our results showed that patients with schizophrenia had lower FA in the frontal aspects of the left A