the association between parental history of diagnosed moodanxiety disorders and psychiatric symptoms and disorders in young adult offspring父母之间的关系的历史诊断moodanxiety障碍和精神症状和障碍在年轻的成年子女.pdf

Low et al. BMC Psychiatry 2012, 12:188 /1471-244X/12/188 RESEARCH ARTICLE Open Access The association between parental history of diagnosed mood/anxiety disorders and psychiatric symptoms and disorders in young adult offspring 1* 2 3 2,4 5 2,4,6 Nancy CP Low , Erika Dugas , Evelyn Constantin , Igor Karp , Daniel Rodriguez and Jennifer O’Loughlin Abstract Background: Parental history of mood or anxiety disorders is one of the strongest and most consistent risk factors for the development of these disorders in offspring. Gaps remain however in our knowledge of whether maternal or paternal disorders are more strongly associated with offspring disorders, and whether the association exists in non-clinical samples. This study uses a large population-based sample to test if maternal or paternal history of mood and/or anxiety disorders increases the risk of mood and/or anxiety disorders, or symptoms of specific anxiety disorders, in offspring. Methods: Data were drawn from the Nicotine Dependence in Teens Study, a prospective cohort investigation of 1293 grade 7 students. Data on mental health outcomes were collected in mailed self-report questionnaires when participants were aged 20.4 (0.7) years on average. Parental data were collected in mailed self-report questionnaires. This current analysis pertains to 564 participants with maternal and/or paternal data. The association between maternal and paternal history and each of diagnosed anxiety disorder, diagnosed mood disorder, and symptoms of specific anxiety disorders in offspring was studied in multivariate logistic regression. Results: A higher proportion of mothers than fathers had a diagnosed mood/anxiety disorder (23% versus 1