single ha2 mutation increases the infectivity and immunogenicity of a live attenuated h5n1 intranasal influenza vaccine candidate lacking ns1单一ha2突变增加了传染性和减毒活疫苗的免疫原性缺乏ns1 h5n1流感疫苗滴鼻候选人.pdf

Single HA2 Mutation Increases the Infectivity and Immunogenicity of a Live Attenuated H5N1 Intranasal Influenza Vaccine Candidate Lacking NS1 1. 1. 2 1 Brigitte M. Krenn , Andrej Egorov *, Ekaterina Romanovskaya-Romanko , Markus Wolschek , 1 1 1 1 1 Sabine Nakowitsch , Tanja Ruthsatz , Bettina Kiefmann , Alexander Morokutti , Johannes Humer , 5 5 5 1 1 1 Janina Geiler , Jindrich Cinatl , Martin Michaelis , Nina Wressnigg , Sanda Sturlan , Boris Ferko , Oleg V. 3 3 4 4 4 2 Batishchev , Andrey V. Indenbom , Rong Zhu , Markus Kastner , Peter Hinterdorfer , Oleg Kiselev , Thomas Muster1, Julia Romanova1 1 Avir Green Hills Biotechnology AG, Vienna, Austria, 2 Influenza Research Institute, Russian Academy of Medical Sciences, St. Petersburg, Russia, 3 A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences (RAS), Moscow, Russia, 4 Christian Doppler Laboratory of Nanoscopic Methods in Biophysics, Institute for Biophysics, Johannes Kepler University Linz, Linz, Austria, 5 Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt, Germany Abstract Background: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic av