spatial-temporal analysis of non-hodgkin lymphoma in the nci-seer nhl case-control study时空分析nci-seer nhl非霍奇金淋巴瘤的病例对照研究.pdf

Wheeler et al. Environmental Health 2011, 10:63 /content/10/1/63 RESEARCH Open Access Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study 1* 2 3 4 5 David C Wheeler , Anneclaire J De Roos , James R Cerhan , Lindsay M Morton , Richard Severson , Wendy Cozen6 and Mary H Ward1 Abstract Background: Exploring spatial-temporal patterns of disease incidence through cluster analysis identifies areas of significantly elevated or decreased risk, providing potential clues about disease risk factors. Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL. Methods: We conducted a population-based case-control study of NHL in four National Cancer Institute (NCI)- Surveillance, Epidemiology, and End Results (SEER) centers: Detroit, Iowa, Los Angeles, and Seattle during 1998-2000. Using 20-year residential histories, we used generalized additive models adjusted for known risk factors to model spatially the probability that an individual had NHL and to identify clusters of elevated or decreased NHL risk. We evaluated models at five different time periods to explore the presence of clusters in a time frame of etiologic relevance. Results: The best model fit was for residential locations 20 years prior to diagnosis in Detroit, Iowa, and Los Angeles. We found statistically significant areas of elevated risk of NHL in three of the four study areas (Detroit, Iowa, and Los Angeles) at a lag time of 20 years. The two areas of significantly elevated risk in the Los Angeles study area were detected only at a time lag of 20