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非霍奇金淋巴瘤NHL综述.pdf

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Seminar

Non-Hodgkinlymphoma

JamesOArmitage,RandyDGascoyne,MatthewALunning,FrancoCavalli

Lymphomascanaffectanyorganinthebody,presentwithawiderangeofsymptoms,andbeseenbyprimarycarePublishedOnline

physiciansandphysiciansfrommostspecialties.TheyaretraditionallydividedintoHodgkin’slymphoma(whichJanuary30,2017

accountsforabout10%ofalllymphomas)andnon-Hodgkinlymphoma,whichisthetopicofthisSeminar.Non-/10.1016/

HodgkinlymphomarepresentsawidespectrumofillnessesthatvaryfromthemostindolenttothemostaggressiveS0140-6736(16)32407-2

malignancies.Theyarisefromlymphocytesthatareatvariousstagesofdevelopment,andthecharacteristicsoftheUniversityofNebraskaMedical

Center,Omaha,NE,USA

specificlymphomasubtypereflectthoseofthecellfromwhichtheyoriginated.Sincethistopicwaslastreviewedin(ProfJOArmitageMD,

TheLancetin2012,advancesinunderstandingthebiologyandgeneticsofnon-HodgkinlymphomaandtheavailabilityMALunningDO);British

ofnewdiagnosticmethodsandtherapieshaveimprovedourabilitytomanagepatientswiththisdisorder.ColumbiaCancerAgencyand

BritishColumbiaCancer

Epidemiolog

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