alzheimers disease and non-demented high pathology control nonagenarians comparing and contrasting the biochemistry of cognitively successful aging阿尔茨海默病和非痴呆病理控制中比较和对比认知成功老化的生物化学.pdf

Alzheimer’s Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging 1 1 1,2 3 1 Chera L. Maarouf , Ian D. Daugs , Tyler A. Kokjohn , Douglas G. Walker , Jesse M. Hunter , Jane C. 3 4 5 ˜ 6 7 Kruchowsky , Randy Woltjer , Jeffrey Kaye , Eduardo M. Castano , Marwan N. Sabbagh , Thomas G. 8 1 Beach , Alex E. Roher * 1The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America, 2 Department of Microbiology, Midwestern University, Glendale, Arizona, United States of America, 3 Laboratory of Neuroinflammation, Banner Sun Health Research Institute, Sun City, Arizona, United States of America, 4 Department of Pathology, Oregon Health Science University, Portland, Oregon, United States of America, 5 Layton Aging and Alzheimer’s Disease Center, Department of Neurology, Oregon Health and Science University, United States of America, 6 Fundacion Instituto Leloir, Buenos Aires, Argentina, 7 Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, Arizona, United States of America, 8 Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, United States of America Abstract The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer’s disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively inta