the clathrin assembly protein picalm is required for erythroid maturation and transferrin internalization in mice所需的网格蛋白组装蛋白质picalm红细胞成熟和转铁蛋白在老鼠身上内化.pdf

The Clathrin Assembly Protein PICALM Is Required for Erythroid Maturation and Transferrin Internalization in Mice 1 2 3 4 4 2 Mai Suzuki , Hirokazu Tanaka , Akira Tanimura , Kenji Tanabe , Natsuko Oe , Shinya Rai , Syunsuke 5 6 4 7 2 3 Kon , Manabu Fukumoto , Kohji Takei , Takaya Abe , Itaru Matsumura , Yuzuru Kanakura , Toshio Watanabe1* 1 Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women’s University, Nara, Japan, 2 Division of Hematology, Department of Internal Medicine, Kinki University, Osaka, Japan, 3 Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan, 4 Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, 5 Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 6 Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 7 Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan Abstract Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;11)(p13;q14). CALM is sufficient to drive clathrin assembly in vitro on lipid monolayers and regulates clathrin-coated budding and the size and shape of the vesicles at the plasma membrane. Ho