唑吡坦联合重复经颅磁刺激治疗失眠症效果.doc

唑吡坦联合重复经颅磁刺激治疗失眠症的效果 　　[摘要] 目的 探讨唑吡坦联合重复经颅磁刺激（rTMS）治疗失眠症的效果，以分析rTMS的临床使用价值。 方法 选择2015年5月～2016年5月在淮安市第三人民医院住院治疗的84例患者，按照随机数字表法将其分为两组，其中对照组患者每晚入睡前口服唑吡坦10 mg，观察组患者在此基础上在给予rTMS治疗。两组患者共治疗2个疗程，1周为1个疗程。观察两组临床疗效，比较两组匹茨堡睡眠质量指数量表（PSQI）评分和各项睡眠参数。 结果 观察组临床有效率显著高于对照组，差异有统计学意义（P 0.05），治疗后两组患者PSQI评分均较治疗前显著下降，差异有统计学意义（P 0.05）。 结论 对于失眠症患者而言，单独使用唑吡坦可取得一定的疗效，但在唑吡坦的基础上给予rTMS治疗，效果更为显著，可以有效改善患者睡眠状况，同时不会增加不良反应，治疗安全性高，值得临床推广 [关键词] 唑吡坦；重复经颅磁刺激；失眠症 [中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2016）09（b）-0112-04 [Abstract] Objective To investigate the effect of Zolpidem combined with repeated transcranial magnetic stimulation （rTMS） in the treatment of insomnia， and to analyze the clinical application value of rTMS. Methods Eighty-four patients with insomnia hospitalized in the Third People′s Hospital of Huai′an City from May 2015 to May 2016 were selected. The subjects were randomly divided into two groups. Before the patients fell asleep every night， the control group orally took 1 mg of Zolpidem， on basis of which， the observation group was given rTMS. Both groups were taken 2 courses of treatment， one week was as a course. The clinical effect of the two groups was observed， the scores of Pittsburg sleep quality index （PSQI） and the parameters of sleeping of the two groups were evaluated. Results The clinical effective rate of observation group was higher than that of control group， the difference was statistically significant （P 0.05）； after surgery， the scores of PSQI in the two groups were all lower than those before surgery （P 0.05）. Conclusion For patients with insomnia， Zolpidem can achieve a certain effect， while， Zolpidem added with rTMS can achieve more significant effect， which can significantly improve the patients’ sleep condition， without increasing adverse reactions， the safety is high， it is worthy of clinical promotion. 　　[Key words] Zolpidem； Repeated transcranial magnetic stimulation； Insomnia 随着人们生活节奏的加快、生活压力的加大，越来越多的人们尤其是都市白领出现失眠症，且症状难以改善。长期的失眠不仅会对患者的身心健康造