多肿瘤标志物蛋白芯片系统(C12)对胃癌诊断的临床价值_临床医学论文-毕业论文_9146.doc
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多肿瘤标志物蛋白芯片系统(C12)对胃癌诊断的临床价值_临床医学论文-毕业论文
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【摘要】? 目的 研究多肿瘤标志物蛋白芯片对胃癌的诊断价值。方法 用C12诊断系统检测50例正常人,60例胃良性疾病及70例胃癌患者血清中常见的十二种肿瘤标志物:甲胎蛋白(AFP),癌胚抗原(CEA),神经原特异性烯醇化酶(NSE),癌抗原125(CA125),癌抗原153(CA153),糖链抗原242(CA242),糖链抗原19-9(CA19-9),前列腺特异性抗原(PSA),游离前列腺特异性抗原(F-PSA),铁蛋白(FER),β-人绒毛膜促性腺激素(β-HCG),人生长激素HGH的水平,进行统计分析。结果 70例胃癌患者血清中有63例血清肿瘤标志物为阳性,阳性率90%;60例胃良性疾病中有9例肿瘤标志物为阳性,阳性率15%;50例正常对照组血清肿瘤标志物中有1例为阳性,阳性率2%。结论 多种肿瘤标志物蛋白芯片的应用,对胃肿瘤良恶性的判定有一定的临床价值。
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【关键词】? 胃癌;蛋白芯片;癌胚抗原;CA-125抗原;CA-19-9抗原;CA242抗原
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??? 【Abstract】? Objective? To investigate the application of multi-tumor markers protein chip diagnostic system in the diagnosis of gastric cancer.Methods? Of the 70 patients with gastric cancer;60 patients who suffered from benign digestive disease and 50 healthy persons served as controls.The contents of alpha fetoprotein(AFP),carcinoembryonic antigen (CEA);neuron-specific enolase(NSE),carbohydrate antigen 125 (CA125),carbohydrate antigen 153(CA153),carbohydrate antigen 242 (CA242),carbohydrate antigen 19-9(CA19-9),prostate specific antigen(PSA),free prostate specific antigen (f-PSA),ferritin(FER),β-human chorionic gonadotrophin(β-HCG) and human growth hormone (HGH) in the serum of 70 patientis with gatric cancer,60 patients with benign digestive disease and 50 healthy persons were determined with multi-tumor markers protein chip assistance diagnostic system and analyzed with statistic method.Results? There were 63 patients (90%) with positive tumor markers in serum in 70 cases of gastric cancer,9 cases(15%) with tumor markers in 60 cases of benign digestive disease and 1 case with tumor markers in 50 cases of normal controls.Conclusion? The application of multi-tumor markers protein chip diagnostic system has certain clinicel value in the diagnosis of gastric cancer before surgery.
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??? 【Key words】? gastric cancer;protern chip;carcinoembryonic antigen;CA-125
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