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Int. J. Mol. Sci. 2012, 13, 336-347; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment Sreenivasan Sasidharan 1,*, Selvarasoo Logeswaran 2 and Lachimanan Yoga Latha 1 1 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia; E-Mail: latha_usm@ 2 Department of Biotechnology, Faculty of Applied Sciences, Asian Institute of Medicine, Science and Technology, 08000 Sungai Petani, Kedah, Malaysia; E-Mail: yogaeswaran@ * Author to whom correspondence should be addressed; E-Mail: srisasidharan@; Tel.: +60 Fax: +60 Received: 21 July 2011; in revised form: 2 November 2011 / Accepted: 28 November 2011 / Published: 28 December 2011 Abstract: Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound heali