surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation表面改性的生物医学和牙科植入物和炎症的过程,伤口愈合和骨形成.pdf

Int. J. Mol. Sci. 2010, 11, 354-369; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation, Wound Healing and Bone Formation Clark M. Stanford Dows Institute for Dental Research, College of Dentistry, University of Iowa, IA 52242, USA; E-Mail: Clark-Stanford@; Tel.: +1-319-335-7381; Fax: +1-319-335-8895 Received: 24 December 2009; in revised form: 18 January 2010 / Accepted: 20 January 2010 / Published: 25 January 2010 Abstract: Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces. Keywords: implant; surfaces; wound healing; macrophage 1. Introduction Endosseous dental implants have created a revolution in the routine approach to dental care for patients missing one or more teeth. The clinical success for this pr