系统性红斑狼疮甲状腺激素变化及相关性研究.doc

精品论文 参考文献 系统性红斑狼疮甲状腺激素变化及相关性研究 陈仁利 高小娟 宋一凡 汤一榕 　　（福建医科大学附属医院宁德市医院血液风湿科352000） 　　【摘要】目的 观察系统性红斑狼疮(SLE)患者血清甲状腺激素水平变化，探讨其与SLE疾病活动度的相关性。方法 检测112例SLE 甲状腺激素水平，将其与疾病活动度（以SLEDAI评价）、血清白蛋白、补体等指标进行比较，并以47名健康检查者作对照。结果 (1)112例SLE患者甲状腺功能异常占52%（58/112），其中合并甲亢2例（1.8），甲减5例（4.4%）,正常甲状腺病态综合征51例（45%）。(2)SLE组血清TT3、TT4、FT3、FT4水平显著低于健康组（P＜0.05），尤以SLE肾炎组更明显（P＜0.05）。(3)SLE组血清TT3，TT4 FT3 FT4水平与血清白蛋白呈正相关（P＜0.05）,而TT3,TT4,FT3与C3呈正相关（P＜0.05）。(4)甲状腺功能异常组的SLEDAI高于甲状腺功能正常组SLEDAI（P＜0.05）。TT3与SLEDAI呈负相关（r=-0.308, P＜0.05）。结论 SLE患者易发生甲状腺功能异常，且血清甲状腺激素水平降低与疾病的活动性有密切关系。 　　【关键词】红斑狼疮 系统性 甲状腺激素 SLE疾病活动指数 　　【中图分类号】R593.24+1 【文献标识码】A 【文章编号】2095-1752（2014）03-0070-02 　　A Study on The Change of Thyroid Hormone Level in Systemic Lupus Erythematosus and Their Relationship 　　【Abstract】Objective To evaluate the change of serum thyroid hormone in systemic lupus erythematosus (SLE) and its relationship with the disease activity. Methods The serum TH level in 112 SLE patients and 47 healthy controls were measured and the relationship among the serum TH level, disease activity (evaluated using SLEDAI), serum albumin and complements was analyzed. Results (1) 52% SLE patients suffered the abnormality of thyroid function, including 2 (1.8%) cases with hyperthyroidism, 5 (4.4%) with hypothyroidism and 51 (45%) with euthyroid sick syndrome. (2) The levels of serum TT3, TT4, FT3, FT4 in SLE patients (especially those with SLE-related nephritis) were significantly lower than those in healthy controls (plt;0.05). (3) There was a positive correlation between the levels of serum TT3, TT4, FT3, FT4 and the level of serum albumin (plt;0.05) and so was found between the levels of serum TT3, TT4, FT3 and the level of C3 (plt;0.05). SLEDAI in SLE patients with the abnormality of thyroid function was significantly higher than that in SLE patients with normal thyroid function (plt;0.05), and there was a negative correlation between the level of TT3 and SLEDAI (r=-