发热症状（Fever symptoms）.doc

发热症状（Fever symptoms） Treatment of fever Unexplained fever too much, this is a difficult question to answer, because too many and complicated, therefore, unexplained fever consulting every day a big basket without the doctor answered, I always felt consultants very helpless, very helpless, so, today I give everybody to introduce from the professional point of view, for reference only understand. I. overview Long-term unexplained fever refers to fever lasting more than two weeks, the temperature is over 38 DEG C, high fever, and the patients were admitted to hospital within a week after the observation, repeated examination failed to confirm the diagnosis of fever (fever of known origin, FUO). Heat type and irregular heat in remittent fever and so on to see other, including continued fever, intermittent fever, brucellosis varies depending on the disease. Two, the occurrence mechanism The body temperature of normal subjects is controlled by the temperature regulating center of the cerebral cortex and hypothalamus. Through the nerve and humoral factors, regulate the process of producing heat and radiation, and keep the body temperature relatively constant. When endogenous pyrogen contribute to thermoregulation, heat generation and scattered hot level increases, but the peripheral temperature regulating mechanism, including skin vascular constriction or dilation, sweat, muscle tension, still maintain the normal and the fever known as endogenous fever. When exogenous pyrogen, including bacteria and endotoxin, viruses, fungi and other microorganisms, tumor necrosis, substance, immune response, activation of monocyte macrophage system, IL-1, TNF and other effects of pyrogen in the hypothalamus thermoregulatory center nerve cells, release four arachidonic acid, promote prostaglandin synthesis, resulting in exogenous fever. Three, common causes There are a variety of clinical classification methods for unexplained long-term febrile diseases, which are divided into two categor