碘海醇注射液（Injection of iodide）.doc

碘海醇注射液（Injection of iodide） Iohexol Injection (Leo parker) This article main ingredients and its chemical name for: iodine alcohol, N, N - double (2, 3-2 hydroxy propyl) - 5 - [N - (2, 3-2 hydroxy propyl) ethyl amide] three iodine - 1-2 minus 2 -, 3 - dimethyl benzene amide. 【 properties 】 This product is colorless to light yellow transparent liquid. This product is a non-ionic water-soluble contrast agent containing three iodine atoms, and the iodine content is 46.4%. It is prepared with disinfected aqueous solution and can be used at any time and has different iodine concentration. It contains 140, 180, 240, 300 or 350mg of iodine per milliliter. [pharmacological toxicology] Pharmacological action: This product is used as a contrast agent for X-ray and CT examination, which can be used in blood vessels, spinal canal and body cavity. The results of animal test showed that this product has enhanced effect on canine liver, abdominal aorta and CT scan images. Toxic effects: The occurrence of proteinuria in canine renal arteriography. [pharmacokinetics] Through intravenous injection into the body of iodide, almost all drugs were discharged in the urine in the original form within 24 hours. One hour after injection, the highest concentration in urine. No metabolites are produced. The hemodynamic parameters, clinical chemical parameters and coagulation parameters of healthy volunteers were different from those before the injection, and their changes were not clinically significant. Rat, rabbit and dog intravenous mainly from the eduction in urine, small (1%) rats by 5%, from the eduction in dung, have not found any organ absorption phenomena, also did not detect any metabolites in animal. This protein binding rate is less than 2% or almost no binding to the protein. [indication] 1, intravascular application of clinical application of this product in the adult and childrens urinary tract imaging and angiography, and adult brain angiography, and various peripheral artery a