systems biology-defined nf-κb regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status系统biology-defined nf-κb调节子,信号通路和网络互动参与的恶性表型的头部和颈部癌症细胞系p53地位不同.pdf

YanVolume 9, Issue 3, Article R53et al.2008 Open Access Research Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status ¤* ¤†‡ *§ * ¶ Bin Yan , Guang Chen , Kunal Saigal , Xinping Yang , Shane T Jensen , * ‡¥ * Carter Van Waes , Christian J Stoeckert and Zhong Chen Addresses: *Head and Neck Surgery Branch, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA. †Department of Bioengineering, Smith Walk; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ‡Center for Bioinformatics, Guardian Drive; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. §NIH-Pfizer Clinical Research Training Program Award; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ¶Department of Statistics, The Wharton School, Walnut Street; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ¥Department of Genetics, School of Medicine, Curie Boulevard; University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ¤ These authors contributed equally to this work. Correspondence: Zhong Chen. Email: chenz@ Published: 11 March 2008 Received: 8 November 2007 Revised: 28 January 2008 Genome Biology 2008, 9:R53 (doi:10.1186/gb-2008-9-3-r53) Accepted: 11 March 2008