systems pharmacology and genome medicine a future perspective系统药理学和基因组医学未来的视角.pdf

Review SSyysstteemmss pphhaarrmmaaccoollooggyy aanndd ggeennoommee mmeeddiicciinnee:: aa ffuuttuurree ppeerrssppeeccttiivvee Aislyn D Wist, Seth I Berger and Ravi Iyengar Address: Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. Correspondence: Ravi Iyengar. Email: ravi.iyengar@ Published: 22 January 2009 Genome Medicine 2009, 11:: 11 (doi:10.1186/gm11) The electronic version of this article is the complete one and can be found online at /content/1/1/11 © 2009 BioMed Central Ltd AAbbssttrraacctt Genome medicine uses genomic information in the diagnosis of disease and in prescribing treatment. This transdisciplinary field brings together knowledge on the relationships between genetics, pathophysiology and pharmacology. Systems pharmacology aims to understand the actions and adverse effects of drugs by considering targets in the context of the biological networks in which they exist. Genome medicine forms the base on which systems pharmacology can develop. Experimental and computational approaches enable systems pharmacology to obtain holistic, mechanistic information on disease networks and drug responses, and to identify new drug targets and specific drug combinations. Network analyses of interactions involved in pathophysiology and drug response across various scales of organization, from molecular to organismal, will allow the integration of the systems-level understanding of drug action with genome medicine. The interface of the two fields will enable drug disc